The stromal cell-derived factor 1 (SDF-1), also known as C-X-C motif chemokine 12 (CXCL12), is a chemokine protein that in humans is encoded by the CXCL12 gene on chromosome 10. It is ubiquitously expressed in many tissues and cell types. Stromal cell-derived factors 1-alpha and 1-beta are small cytokines that … See more Gene The CXCL12 gene resides on chromosome 10 at the band 10q11.1 and contains 9 exons. This gene produces 7 isoforms through alternative splicing. Protein See more CXCL12 is expressed in many tissues in mice including brain, thymus, heart, lung, liver, kidney, spleen, platelets and bone marrow. CXCL12 is strongly chemotactic for lymphocytes. During embryogenesis, it directs the migration of hematopoietic cells from fetal See more In humans, CXCL12 has been implicated in a wide variety of biomedical conditions involving several organ systems. Furthermore, … See more • Kucia M, Reca R, Miekus K, Wanzeck J, Wojakowski W, Janowska-Wieczorek A, Ratajczak J, Ratajczak MZ (August 2005). "Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF-1-CXCR4 axis" See more WebApr 10, 2024 · SDF-1α-aligned SF nanofiber promoted regeneration of urethral mucosa, submucosal smooth muscles, and microvasculature, increased cellular proliferation, and reduced collagen deposition. SDF-1α expression was increased in reconstructed urethra at 3 months post-surgery in SDF-1α-aligned SF group.
Activation of signal transducers and activators of ... - PubMed
WebMesenchymal stem or stromal cells (MSC) have proven to offer great promise for cell-based therapies and tissue engineering applications, as these cells are capable of extensive self-renewal and display a multilineage differentiation potential. Furthermore, MSC were shown to exhibit immunomodulatory properties and display supportive functions through … WebStromal cell-derived factor 1 alpha (SDF-1α) is a member of the CXC group of chemokines that binds to the G-protein coupled receptor, CXCR4, to regulate migration, proliferation, differentiation, and survival of many cell types including hematopoietic stem cells, B … brother dr420 drum toner package
Stromal cell derived factor-2 (Sdf2): A novel protein expressed in ...
WebMar 3, 2024 · MSCs-derived exosomes promoted the cell cycle of hFOB 1.19 cells, a type of osteoblast, and activated their proliferative activity through the MAPK pathway. It was also found that overexpression of miR-122-5p in MSCs-derived exosomes of bone marrow can increase the BMD of the femoral head through the MAPK pathway[ 26 ]. WebMar 15, 2002 · SDF-1 pretreatment was performed by incubating the prostate cancer cells with 0–200 ng/ml SDF-1 (or 200 ng/ml SDF-1 that had been boiled for 15 min as a negative control) for 30 min at 37°C. Cell-to-cell adhesion was allowed to proceed for 30 min at 37°C. WebMesenchymal stem or stromal cells (MSC) have proven to offer great promise for cell-based therapies and tissue engineering applications, as these cells are capable of extensive self … brother dr360 toner